Glossary about MEBT/MEBO

Tissue Organ:
A tissue unit consists of more than one type of cells in human organs, which exert one or more than one life functions in human lives.

Tissue Organ Regenerative Nutritious Components:
Cell nutritious components in vivo and in vitro, which could activate and maintain the process of cell proliferation and differentiation and finally form tissue organs.

In situ Regeneration:
The damaged or necrotic cells in organs regenerate into live tissue cells, tissues or organs in situ. This regeneration is not transplantation of cells, tissue or organs from in vitro.

MEBT/MEBO (Moist Exposed Burn Therapy/Ointment):
It was invented in the 1980s by Professor Rongxiang Xu. MEBO is a botanic drug consisting of multiple botanic components and animal nutritional ingredients cooperated with a unique patented sponge-like frame structure dosage form to treat various (depth/TBSA/cause) burns, wounds and ulcers in regeneration of skin organ.

The Chinese Burn Association of the Integration of Traditional and Western Medicine (CBAIM) was officially founded on December 28,1996; it is an independent, not-for-profit organization dedicated to stimulating and supporting burn-related research, education, care, rehabilitation, and prevention. Especially to worldwide spread and popularize the Burns Regenerative Therapy, which is an innovation in burn care field, proposed by Prof. Xu Rongxiang. To advance these goals, the CBAIM sets up a national medical network with many burn centers and hospitals to provide first aid service and medical supervision, sponsors a variety of educational programs, fellowships, research, teaching and publications.

Recovery stars:

From 1998, the CBAIM appraise about 10 Burn Recovery Stars each year from numerous of depth burn patients, the total burn body surface area of them all exceeded 90% and they were successfully salvaged and cured with Burn Regenerative Therapy (BRT).

Adult stem cell
An undifferentiated cell found in a differentiated tissue that can renew itself and (with certain limitations) differentiate to yield all the specialized cell types of the tissue from which it originated.

Burns are classified according to the depth of the burn. In partial-thickness burns some part of the stratum basale remains viable, and regeneration of the epidermis occurs from within the burn area as well as from the edges of the burn. Partial-thickness burns are divided into first-and second-degree burns.

First-degree burns involves only the epidermis and are red and painful, and slight edema, or swelling, can be present. They can be caused by sunburn or brief exposure to hot or cold objects, and they heal without scarring in about a week.

Second-degree burns damage the epidermis and the dermis. If there is minimal dermal damage, symptomas include redness, pain, edema, and blisters. Healing takes about 2 weeks, and there is no scarring. If the burn goes deep into the dermis, however, the wound appears red, tan, or white; can take several months to heal; and might scar. In all second-degree burns, the epidermis regenerates from epithelial tissue in hair follicles and sweat glands, as well as from the edges of the wound.

In full-thickness, or third-degree, burns the epidermis and the dermis are completely destroyed, and recovery occurs from the edges of the burn wound. Third-degree burns often are surrounded by areas of first- and second-degree burns. Although the first- and second-degree burn areas are painful, the region of third- degree burn is usually painless because sensory receptors in the epidermis and dermis have been destroyed. Third-degree burns apear white, tan, brown, black, or deep cherry red.

Deep partial-thickness and full-thickness burns take a long time to heal, and they form scar tissue with disfiguring and debilitating wound contracture. To prevent these complications and to speed healing, skin grafts are often performed. In a split skin graft the epdermis and part of the dermis are removed from another part of the body and placed over the burn. Interstitial fluid from the burn nourishs the graft until blood vessels grow into the graft and supply it with nourishment. Meanwhile, the donor tissue produces new epidermis from epith epithelial tissue in the hair follicles and sweat glands in the same manner as in superfical second-degree burns.

Is the abbreviation of Burns Regenerative Therapy, established by Professor Rongxiang Xu, is an innovative therapeutic system completely different from the conventional burn management, both in concept and in practice. This new approach is aimed at treating damaged tissue organs in skin by potentiating and stimulating Potential Regenerative Cells and Stem Cells in situ and thereby directly repairing and regenerating tissues of the skin without transplantation.

A fluid that has exuded out of a tissue or its capillaries due to injury or inflammation.

Embryonic stem cells
Primitive (undifferentiated) cells from the embryo that have the potential to becomea wide variety of specialized cell types.

In vitro
Literally, "in glass"; in a laboratory dish or test tube; an artificial environment.

In situ
A Latin phrase meaning “in the original location.” In scientific experimentation, it refers to experiments conducted in the actual site of the phenomenon under study, in contrast to in vitro (outside the living body and in an artificial environment) and in vivo (in the living body of a plant or animal).

Is the abbreviation of Moist Exposed Burn Therapy and Moist Exposed Burn Ointment( a patented burn ointment), the revolutionary and practical burn therapy invented by Prof. Xu Rongxiang, it consists of two clinical system: the local treatment of burns wound and the systemic treatment of burns. it contains series of theories and applied techniques. Clinically, this therapy is carried out through MEBT and MEBO.

Potential regenerative cells (PRCs)
The special mature tissue cell discovered by Dr. Xu, which has the potential ability to regenerate to a functional tissue similar as stem cell but normally exists in tissue as a tissue cell. It can also be called as the special differentiated tissue cell coming from proliferating cell during different development stages in all types of organs in the organism .

Stem cells
Cells with the ability to divide for indefinite periods in culture and to give rise to specialized cells.

Ploughing Relaxation Technique
This technique is to apply specially made surgical instruments “Plough Saw Blade” or operating knife, rolling knife to cut wound surface, forming scratch about 1mm in spacing and depth to relieve the tension of degenerative and necrotic epithelial tissue; help subdermal vascular plexus in circuit, initiate and activate PRCs of residual skin tissue and regenerate skin organ in situ.

Fibrous isolation membrane
MEBO has good compatibility with burn wound exudates and can form a fibrous isolation membrane in the course of wound necrotic tissue liquefaction. The membrane is composed of lipoids produced by the biochemical reactions of MEBO and lipoproteins complexes produced by exudates of plasma protein from wounds. The membrane tightly covers the wound surface, so that the neo regenerative stuff can attached to it and the wounds can be repaired in a regenerative way in physiologically moist environment.

MEBO has net-like frame form. It's composed by grease and surrounding beeswax. There are abundant linoleic acids (belongs to non-saturation acid), which can be decomposed with sterol stuff, aldehyde oxide, keton oxide, lipid, adipoidand, etc. This process is called “lipofication".

Three No principles”
“Three No principles” of MEBO application: no pain on wounds, no bleeding and no injury to living tissues.

"Three timely principles"
"Three timely principles" is one important principle in the management of wounds; Timely removal of liquefied products, timely removal of necrotic tissue and timely application of the drug (MEBO).

"Three no accumulation"
"Three no accumulation" is one important principle in the management of wounds; no accumulation of necrotic tissue, no accumulation of liquefied products and no accumulation of excessive drug (MEBO).