MEBO for Treating Idiopathic Gangrene of Scrotum

MEBO is capable of promoting wound healing and has strong effect against Streptococcus and Staphylococcus aureus infections.

MEBO gauze was applied every 8 hours to the lesion area and necrotic tissue was removed timely.

Idiopathic gangrene of scrotum is a rare disease caused by bacterial infection. 

The main pathogens are Streptococcus hemlyticus, Staphylococcus aureus, Escherichia coli and Bucillus proteus etc. [1]. 

Scrotal gangrene usually injures the full thickness skin and the serious scrotal gangrene will also affect testes and tunica vaginalis testis to make the testes and common sheath of testis and spermatic cord exposed. 

The scrotum is located at the medial part of thighs that is close to the anus and meatus urinarius. Besides, the scrotal skin is loose, soft and winkled. 

Consequently, the scrotum is often infected by the bacteria staying on it from the anus and meatus urinarius or the bacterial embolus staying on it carried by blood from other infected part. 

The traditional therapy is to strengthen local and systemic anti-infection and treat local part with traditional surgical therapy of dressing change.

There is still no report about MEBO in treating idiopathic gangrene of scrotum. On the basis of MEBO in treating burn wounds, we treated 2 cases of idiopathic gangrene of scrotum with MEBO. Hereinafter, we analyze its effect in detail.

In fact, the wounds of the 2 cases were basically similar to that of third-degree burn wounds. The therapy of MEBO is coordinate with the therapeutic principle of MEBT. 

The main elements of MEBO are the lactone of Cortex Phellodendri and β- sitosterol that are derivants of triterpenoid[2]. The lactone of Cortex Phellodendri and β- sitosterol, as surface active agents, have hydrophilic gene and oleophylic gene, so they have the functions of wetting, osmosis, emulsification, solubilization and cleaning. 

MEBO supplies for tissues a growth environment which is moist but not macerated. Its matrixes take hydrolysis, enzymolysis, sponification and acidification with the necrotic tissue of wound to automatically and intactly liquefy and eliminate the necrotic tissue of wound from superficies to interior in order to remove necrotic tissue and promote tissue regeneration. 

Dr. Xu’s Theory believes: the anti-infectious mechanism of MEBO is to destroy the environment for bacterial growth and reproduction.  Namely, its internal environment of constant liquefaction and unobstructed drainage discharges a great deal of bacteria out of the wound. 

Moreover, MEBO also can prevent bacterial reinvasion and wound injury, so as to fundamentally prevent the wound from worsening and deepening caused by the infection of Streptococcus hemlyticus and Staphylococcus aureus, and finally achieve the healing of wound.

Generally, the wound treated with MEBO need not receive skin grafting.

Full Report: 
MEBO for Treating Idiopathic Gangrene of Scrotum, The Chinese Journal of Burns Wounds and Surface Ulcers 1999, (4): 22-23