Mechanism of MEBT/MEBO Relieving Pain

Moist burn medical treatment includes Moist Exposed burn Therapy and Moist Exposed Burn Ointment. 

The pain relieving effect of MEBT/MEBO is not the anesthetic action. 

What's the mechanism of the pain relieving effect of MEBT/MEBO? 

First, from the pathological change of the burn wound: 

mebo burn skin

There are mainly three pathological changes after burn: 

After MEBO is smeared onto the wound, the pain caused by the previously mentioned pathological changes can be eased gradually. 

First, MEBO acts with the necrotic tissues of the wound and forms a protective membrane on the vital tissues to protect the exposed nerve endings, then the stimulus of detergent, iatrogenic treatment, harmful gas in the air and temperature change to the nerve endings is avoided so as to achieve pain relieving effect. 

Second, conferted lanugo exists on the skin surface. 

There is a musculi arrectores pilorum at the basilar part of each lanugo. 

When superficial burns occur, the musculi arrectores polorum is at the state of spasm, ischemia and hypoxia because of the irritation so that the patients feel distention and pain. 

The berberine contained in MEBO has the effect of dilating the smooth muscles to loose the musculi arrectores polorum and relieve pain. 

Third, the skin and subcutaneous tissue microcirculation after burn is in stasis or blocking state. 

The blood vessel endothelium damage occurs, so the permeability increases, pachemia and the slow-moving blood flow occur, which will lead to tissue hypoxia and the accumulation of the acidic metabolic products that will cause pain inevitably. 

Baicalin contained in MEBO can relieve capillary spasm, improve microcirculation. 

The unique frame dose of MEBO can keep the burn wound in a three-dimensionally physiological moist environment, which can maximally reduce the moisture evaporation on the burn wound and relieve pachyemia and stasis of the microcirculation. 

It's favorable for the transportation of all kinds of metabolic wastes and reducing their local accumulation. 

Then pain will be relieved. 

All in all, the early application of MEBT to the burn wound in the combination with MEBO can relieve pain in 5~10 mins.