MEBO Patch for Repairing Perforation of Tympanic Membrane

Although the perforation of tympanic membrane caused by chronic otitis media suppurativa is one of clinical common diseases, it is difficult to natural cure.  It not only harms the patient’s auditory but also always leads to recurrence of tympanitis.

We had treated it with the therapy of MEBO sticking pieces to improve the healing of tympanic membrane since 1993 to 1997.

The curative effects are satisfying. 

All the cases were ambulatory (simple) chronic otitis media suppurativa. Among them, 31 cases (36 ears) were male and 12 cases (15 ears) were female. They were 15~52 year-old and averagely 29.3 year-old. The longest case history was 31 years and the shortest was 6 months. The degree of perforation: 23 cases (27 ears) were small-sized perforations (diameter < 3mm), 18 cases (22 ears) were middle-sized perforations (diameter 3~5mm) and 2 cases (2 ears) were large-sized perforations (diameter > 5mm). Through examination, the auditory tubes of all cases were unobstructed and all the ears keep dry over 1 year.

Material & Therapy

1 Material making:

Sheared sterilized gauze to round pieces which diameters were larger 2mm than those of the perforation of tympanic membrane according to the perforation. Then, uniformly applied MEBO onto the gauze (sticking pieces) until the sticking pieces were moist but have no superfluous ointment.

2 The Therapeutic Method:

Disinfected the external auditory canals with 70% alcohol, used extremely thin cotton sticks or lunate pliers to apply cotton threads with 50% trichloroacetic acid and burn the edge around perforation of tympanic membrane with medical cotton threads till emerge 0.5mm white edge. Then, gently and flatly applied MEBO sticking pieces with lunate pliers onto tympanic membrane to completely cover the perforation. During application of sticking pieces, prevented upper respiratory tract infection, strictly prohibit nip nose and let water into ears. Every 5 days, applied a little MEBO onto the pieces to keep moist with small cotton sticks. For small-sized perforations, took out the sticking pieces after 20 days, and for middle- and large- sized perforations, took out after 1 month.


MEBO is a traditional Chinese chemical ointment with mainly elements of Cortex Phellodendri, beeswax, sesame oil and etc.. Besides, traditional Chinese and Western pharmacology and histological observation have proved that MEBO not only possesses detoxiifing and myogentic functions, but also can improve the regeneration of wounds and granulation tissues, accelerate the blood circulation of wounds to guarantee sufficient provision of oxygen and nutrient, develop local metabolism and epithelial healing. [1]

Burn the edge around perforation of tympanic membrane with 50% trichloroacetic acid to form artificial wounds. This therapy sufficiently utilize the promoting function for epithelial growth of MEBO and the “bridge” function of sticking pieces, in order to make neoformative pellicle layer of tympanic membrane concentrically grow along the sticking pieces and regenerative epithelial tissues cover along mucous layer to enhance the healing of perforated tympanic membrane. Besides, MEBO itself has antisepsis and antiphlogistic functions, cause bacterial to mutate and reduce the toxicity and invasiveness of pathogenic bacteria. [2]

Consequently, the cases in this group were not treated with antibiotic but none was infected. The treatment result showed that the effect of MEBO in treating small-sized perforations was significantly superior to that in treating middle and large-sized perforations.

Namely, the smaller perforation of tympanic membrane were, the easier the wounds healed. This therapy is suitable to be used among basal hospitals for its convenience and economy. Furthermore, its materials are also easy to get.

This study finds that this therapy cannot achieve ideal curative effects, so it is not suitable to treat perforations of tympanic membrane > 5mm. In this study, during the all treatment course, insist to use the same sticking piece and apply drug every 5 days.

 It is speculated that if perforated tympanic membrane tissues are not berepaired, it will help the reparation of perforated tympanic membrane by changing sticking pieces and adding the times of dressing change during the treatment course.

Full Report:
MEBO Patch for Repairing Perforation of Tympanic Membrane, The Chinese Journal of Burns Wounds and Surface Ulcers 1999, (4): 20-21