Successful Combined Treatment with Total Parenteral Nutrition Fluid

Cho KY et al. J Korean Med Sci 2007; 22: 588-94
Extravasation injuries in the neonatal intensive care unit are not rare during parenteral hyperalimentation.  There have been many different methods of management. We report five premature infants with wounds of hyperalimentation fluid extravasation managed by the mixture of antibacterial ointment (Terramycin ophthalmic ointment) and MEBO (ASH mixture).  The mean gestational age of patients was 31+2 weeks (range, 28+4 to 35+6 weeks), and the mean weight at extravasation was 1,930 g (range, 1,140 to 2,680 g).  Extravasation occurred within the mean of 32 days (range, 17 to 50 days).  The method of dressing was application of a thick layer of this mixture covered by vaseline and wet gauze renewed at an interval of 8-12 hr after irrigating the wounds thoroughly with normal saline.  The mean duration of dressing was 30 days (range, 20-50 days).  The wounds had healed completely leaving a small size of contracture without functional abnormality. 
This therapy may be considered for an alternative treatment and warrants clinical trials for the confirmation of the local management of extravasation injury.  Patients included were preterm infants admitted from December 2003 to March 2004 in the neonatal intensive care unit of Ewha Womans University Mokdong Hospital.  They were included after obtaining a signed informed consent from their parents.  The procedures followed in the study were in accordance with the recognized ethical standards and with the Helsinki Declaration.